Company Overview

Arbele is dedicated to revolutionizing the treatment of gastrointestinal cancers through the development of cutting-edge immunotherapy platforms. Our mission is to provide hope and improved outcomes for patients battling stomach, pancreas, colon, bile duct, and liver cancers.

Arbele's Vision & Mission

Arbele is driven by a vision to revolutionize cancer treatment through innovative immunotherapy solutions. Our dedicated team of experts is committed to developing antibody-based biologics that target gastrointestinal cancers, including stomach, pancreas, colon, bile duct, and liver. With a focus on inventing proprietary immunotherapy platforms, we aim to accelerate the development of effective treatments for patients in need. Join us on this transformative journey as we strive to make a lasting impact in the field of biotechnology and biopharmaceuticals.

Image of the lower GI tract in the hands of a doctor
Team

Meet Arbele’s Leadership

Get to know the dedicated professionals leading the charge in biotechnology advancements.

John Luk, DMedSc, EMBA
CEO & Founder

John is a distinguished leader in biotechnology, bringing a wealth of expertise to our company. Over an illustrious 18-year academic career, he served as a professor in the US, Hong Kong, and Singapore, contributing significantly to the scientific community with over 200 publications in top-tier journals such as NEJM, Cell, Nature Medicine, and Nature Genetics. Renowned for identifying and patenting CDH17 at Hong Kong University, now licensed to Arbele, John transitioned to the pharmaceutical industry in 2011, taking senior roles at Roche China and Janssen Pharmaceutical, leading drug discovery in oncology, immunology, and hepatitis. He holds honorary professorships across Asia and has been a visiting associate professor at Harvard. John earned his DMedSci from Karolinska Institute, trained as a postdoctoral fellow at Harvard Medical School, and received his EMBA from the Chinese University of Hong Kong.

Dennis Wong, MD
Chief Medical Officer

Dennis brings over 20 years of experience in drug development and clinical research, with pivotal roles at Roche, Genentech, Bristol-Myers Squibb (BMS), and Sanofi. At BMS, he was Group Director for Global Clinical Research in Immunoscience. Formerly, he was Vice President of Clinical Development and Head of Asia Pacific Development at Sanofi. Dennis has served as a assistant professor at the University of California, San Francisco, the University of Chicago, the University of Tokyo, and Virginia Commonwealth University. He is board certified in internal medicine, allergy, and immunology, with extensive regulatory experience including FDA and EMEA filings. Dennis completed his medical training at the University of Manitoba and conducted research at Harvard Medical School. His expertise drives our mission to revolutionize cancer treatment.

Khim Poon, MS App Fin
Chief Operating Officer

Khim has been working in the Banking industry for more than thirty years. With that she brings extensive finance related and risk management expertise to our team. Her banking career span over different countries including Singapore, Australia and Hong Kong working in banks like Banque Nationale de Paris, Citibank, ING Bank, Standard Chartered Bank and also Development Bank of Singapore. Her mainstream of works covers risk management (credit, reputation, operations), business controls (due diligence, sales/business surveillance, regulatory compliance, processes) and strategic management (people, cost/budget, business development and planning, project management). She has also worked in Bearing Point Consulting managing the business strategies of the Retail Banking Finance Advisory. Khim is currently the Chief Operating Officer, pivotal in driving our company’s operational excellence and growth. She holds a Bachelor of Economics from the University of Western Australia and a Master of Applied Finance from the University of Technology Sydney Australia.

Tony Wong, PhD
Chief Technology Officer

Tony has over a decade of drug development experience in multinational pharmaceuticals and biotech startups, specializing in target discovery, lead optimization, and IND-enabling studies. He has expertise in small-molecule drugs, biologics, and CAR-T/NK therapies. His career includes roles as a Senior Scientist at Janssen, co-leading hit identification and lead optimization projects, and at Roche Pharma Research & Early Development. He has also held research positions at the Cancer Science Institute, National University of Singapore, and The University of Hong Kong. Tony has published more than 33 peer-reviewed articles, holds 4 patents, and has written 4 book chapters. His accolades include the Outstanding Young Scientist Award and the “50 Highest-rate Abstracts” Award at the 2019 ASCO Breakthrough Summit. Tony receives his Ph.D. in Biomedical Sciences from The University of Hong Kong.

Jovey Chan, LLB, LLM (CFL)
Chief Legal Officer

Jovey brings a wealth of experience and a robust legal acumen to our leadership team. Throughout her career, Jovey has held pivotal roles in listed groups in Hong Kong, where she played a critical part in strategic decision-making and legal oversight, ensuring the alignment of legal strategy with business objectives. She holds a Bachelor of Law and a Postgraduate Certificate in Law from the University of Hong Kong, and a Master’s in Corporate Finance from The Hong Kong Polytechnic University.

Cindy Shek, BA
Co-founder & General Manager

Cindy brings extensive administrative experience from her tenure at Queen Mary Hospital, where she served from 1992 to 2009. As Acting Senior Hospital Administrator from 2008 to 2009, she managed the Planning & Commissioning Department, overseeing general office management, domestic services, hospital security, carpark management, and medical equipment maintenance. In her role with the Secretariat, Community & Communication Section, Cindy was responsible for the day-to-day operations of the Central General Office, providing secretariat support to key committees, organizing fundraising activities, and preparing executive reports. Her comprehensive experience in hospital administration and operations positions her as a vital asset to our leadership team. Cindy receives her Bachelor of Arts (Hon) in Public and Social Administration from City University of Hong Kong.

Be a Part of Our Success!

Visit our careers page to find out more about our open positions.

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Khim Poon, MS App Fin
Chief Operating Officer

Khim has been working in the Banking industry for more than thirty years. With that she brings extensive finance related and risk management expertise to our team. Her banking career span over different countries including Singapore, Australia and Hong Kong working in banks like Banque Nationale de Paris, Citibank, ING Bank, Standard Chartered Bank and also Development Bank of Singapore. Her mainstream of works covers risk management (credit, reputation, operations), business controls (due diligence, sales/business surveillance, regulatory compliance, processes) and strategic management (people, cost/budget, business development and planning, project management). She has also worked in Bearing Point Consulting managing the business strategies of the Retail Banking Finance Advisory. Khim is currently the Chief Operating Officer, pivotal in driving our company’s operational excellence and growth. She holds a Bachelor of Economics from the University of Western Australia and a Master of Applied Finance from the University of Technology Sydney Australia.

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Cindy Shek, BA
Co-founder & General Manager

Cindy brings extensive administrative experience from her tenure at Queen Mary Hospital, where she served from 1992 to 2009. As Acting Senior Hospital Administrator from 2008 to 2009, she managed the Planning & Commissioning Department, overseeing general office management, domestic services, hospital security, carpark management, and medical equipment maintenance. In her role with the Secretariat, Community & Communication Section, Cindy was responsible for the day-to-day operations of the Central General Office, providing secretariat support to key committees, organizing fundraising activities, and preparing executive reports. Her comprehensive experience in hospital administration and operations positions her as a vital asset to our leadership team. Cindy receives her Bachelor of Arts (Hon) in Public and Social Administration from City University of Hong Kong.

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Jovey Chan, LLB, LLM (CFL)
Chief Legal Officer

Jovey brings a wealth of experience and a robust legal acumen to our leadership team. Throughout her career, Jovey has held pivotal roles in listed groups in Hong Kong, where she played a critical part in strategic decision-making and legal oversight, ensuring the alignment of legal strategy with business objectives. She holds a Bachelor of Law and a Postgraduate Certificate in Law from the University of Hong Kong, and a Master’s in Corporate Finance from The Hong Kong Polytechnic University.

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Tony Wong, PhD
Chief Technology Officer

Tony has over a decade of drug development experience in multinational pharmaceuticals and biotech startups, specializing in target discovery, lead optimization, and IND-enabling studies. He has expertise in small-molecule drugs, biologics, and CAR-T/NK therapies. His career includes roles as a Senior Scientist at Janssen, co-leading hit identification and lead optimization projects, and at Roche Pharma Research & Early Development. He has also held research positions at the Cancer Science Institute, National University of Singapore, and The University of Hong Kong. Tony has published more than 33 peer-reviewed articles, holds 4 patents, and has written 4 book chapters. His accolades include the Outstanding Young Scientist Award and the “50 Highest-rate Abstracts” Award at the 2019 ASCO Breakthrough Summit. Tony receives his Ph.D. in Biomedical Sciences from The University of Hong Kong.

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Dennis Wong, MD
Chief Medical Officer

Dennis brings over 20 years of experience in drug development and clinical research, with pivotal roles at Roche, Genentech, Bristol-Myers Squibb (BMS), and Sanofi. At BMS, he was Group Director for Global Clinical Research in Immunoscience. Formerly, he was Vice President of Clinical Development and Head of Asia Pacific Development at Sanofi. Dennis has served as a assistant professor at the University of California, San Francisco, the University of Chicago, the University of Tokyo, and Virginia Commonwealth University. He is board certified in internal medicine, allergy, and immunology, with extensive regulatory experience including FDA and EMEA filings. Dennis completed his medical training at the University of Manitoba and conducted research at Harvard Medical School. His expertise drives our mission to revolutionize cancer treatment.

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John Luk, DMedSc, EMBA
CEO & Founder

John is a distinguished leader in biotechnology, bringing a wealth of expertise to our company. Over an illustrious 18-year academic career, he served as a professor in the US, Hong Kong, and Singapore, contributing significantly to the scientific community with over 200 publications in top-tier journals such as NEJM, Cell, Nature Medicine, and Nature Genetics. Renowned for identifying and patenting CDH17 at Hong Kong University, now licensed to Arbele, John transitioned to the pharmaceutical industry in 2011, taking senior roles at Roche China and Janssen Pharmaceutical, leading drug discovery in oncology, immunology, and hepatitis. He holds honorary professorships across Asia and has been a visiting associate professor at Harvard. John earned his DMedSci from Karolinska Institute, trained as a postdoctoral fellow at Harvard Medical School, and received his EMBA from the Chinese University of Hong Kong.

Strategic Partnerships

Arbele welcomes visionary partners to join us in revolutionizing cancer treatment with next-generation immunotherapy, in the following areas:

* Drug co-development in different phases, especially Ph2/pivotal trials
* ADC -- novel linker and payload
* CAR-T/NK -- gene editing and allogeneic off-the-shelf
* IVD companion diagnostics -- registration and marketing/ commercialization